The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

The chick embryo chorioallantoic membrane (CAM) serves as a crucial model for studying angiogenesis due to its extensive vascularization and accessibility. It facilitates research on both pro-angiogenic and anti-angiogenic substances, as well as tumor growth and metastasis. The CAM allows for the observation of tumor grafts, which initially remain avascular but later attract blood vessels, enabling rapid growth. Additionally, the model is utilized to explore tumor cell invasion and the effects of anti-angiogenic treatments on vascularization and tumor progression.