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Sydney Brenner's journey from South Africa to becoming a prominent figure in molecular biology is marked by significant achievements, including his education at the University of Witwatersrand and a D.Phil from Oxford. He directed the MRC Laboratory of Molecular Biology in Cambridge and founded the Molecular Science Institute in Berkeley. As a Distinguished Professor at the Salk Institute, he contributed to the field until his later years, influencing biomedical research in Singapore as an A*Star Senior Fellow. His legacy reflects a profound impact on scientific advancement.