Valproate

Viac o knihe

Since its discovery as an anticonvulsant in 1962, valproate has become a leading antiepileptic drug for various seizure types. Its clinical applications have expanded beyond epilepsy to include bipolar disorders and migraines. This volume focuses on the scientific background of valproate, detailing its pharmacological and toxicological profiles and its development into a widely used treatment, marking a significant milestone in drug therapy. Experts will review the current understanding of valproate, discussing new hypotheses regarding its mechanisms of action, metabolism into active metabolites, unique distribution characteristics, and potential adverse effects such as hepatotoxicity and teratogenicity. The text also covers the diverse pharmaceutical formulations of valproate, including innovative controlled-release options. Targeted at neurologists, psychiatrists, and basic scientists in epilepsy research, the monograph also addresses structure-activity relationships of valproate and its metabolites, making it a valuable resource for researchers in medicinal chemistry, especially within the pharmaceutical industry.