Silicon-mediated transformations of functional groups

Viac o knihe

In this comprehensive work, expert Helmut Vorbrüggen provides organic and bioorganic chemists with valuable insights for preparative synthesis. While many chemists are familiar with silylation for protecting functional groups, this book explores the dual concept of protection and simultaneous silylating-activation of various functional groups, including amides and ureas. This innovative methodology creates numerous synthetic pathways and facilitates the elimination of water in its volatile persilylated form under mild reaction conditions, often more advantageous than traditional methods. The monograph's compact format and clear structure make it an essential reference. Key topics include: Introduction; Techniques of Preparative Silylations-Desilylations; Preparation and Properties of Siliconoxy-Leaving Groups; Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide; Reactions of Aldehydes and Ketones; Reactions of Alcohols, Ethers, and Epoxides; Reaction of N-O Systems; Reactions of S-O and Se-O Systems; Cyclizations and Ring Enlargements; Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol; Peterson Reactions; Formation of Carbon-Phosphorous Double- and Triple Bonds; Reductions and Oxidations; Dehydration-Activation and Silylation of Inorganic and Organic Salts and Metalorganic Compounds; and Formation of Polymers.