Mechanisms of metallocenter assembly

Mechanisms of Metallocenter Assembly summarizes the general principles and mechanisms involved in protein metallocenter assembly and illustrates these themes with specific examples. It provides a mechanistic framework for understanding how metals are incorporated into proteins, as well as a systematic analysis of the various options available to the cell for controlling metal incorporation. The authors discuss the importance of metallocenter assembly in the activation of several enzymes and selected structural proteins. The possible reasons why expression of the structural gene is not enough to obtain a functional metalloprotein also are well covered. Mechanisms of Metallocenter Assembly currently is the only book that brings together experimental findings previously scattered in the literature on the mechanisms of metal incorporation into proteins. This book is intended for biochemists, microbiologists, inorganic chemists, and other scientists who are interested in proteins that possess metal ions or metal cofactors.