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Characterization of adhesion ligand phosphorylation in the malaria parasite Plasmodium falciparum (Welch, 1897)
Autori
Viac o knihe
Aims of this study: Phosphorylation is an essential protein modification and has a vital impact on the invasion process of the malaria parasite into the red blood cell. One kinease - PKA - was already proven to participate in invasion by phosphorylating the cytoplasmic domain of the essential invasion protein AMA1. This phosphorylation had tremendous impact on AMA1 function and substitution of the phosphoacceptor site leads to a loss of AMA1 function. This work analyzes phosphorylation of cytoplasmic domains of invasion related parasites ligands and the responsible kinases. It is focused on Rh2b.
Variant knihy
2013, pevná
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